Samuel Brown may refer to:

• Samuel Brown (Royal Navy officer) (1776–1852), English pioneer suspension bridge engineer and inventor
• Samuel Brown (engineer) (1799–1849), English inventor of early internal combustion engine
• Samuel Brown (Wisconsin politician) (1804–1874), American pioneer and politician in Milwaukee, Wisconsin
• Samuel Robbins Brown (1810–1880), American missionary to China
• Samuel Gilman Brown (1813–1885), American educator
• Samuel Morison Brown (1817–1856), Scottish chemist, poet and essayist
• Samuel Brown (Oregon politician) (1821–1886), American pioneer and politician
• Samuel S. Brown (1842–1905), American businessman, racehorse owner/breeder, racetrack owner
• Samuel Brown (mayor) (1845–1909), mayor of Wellington, New Zealand
• Samuel Brown (cricketer) (1857–1938), English cricketer
• Samuel Lombard Brown (1858–1939), Irish politician and barrister
• Samuel McConnell Brown (1865–1923), Australian politician
• Samuel Brown (Alberta politician) (1872–1962), provincial politician from Alberta, Canada
• Samuel Joseph Brown Jr. (1907–1994), African American watercolorist, printmaker, and educator
• Samuel J. Brown (1917–1990), United States Air Forces fighter pilot
• Samuel Ashley Brown (1923–2011), English professor at the University of South Carolina
• Samuel Brown (American football) (born 2002), American football player
• SS Samuel Q. Brown, a steam tanker

• Samuel Browne (disambiguation)
• Sam Brown (disambiguation)
• Sam Browne (disambiguation)