Samuel Adams (1722–1803) was a Boston leader in the era of the American Revolution.

Samuel Adams or Sam Adams may also refer to:

• Samuel Adams (Arkansas politician) (1805–1850), acting Governor of Arkansas in 1844
• Sam Adams (Oregon politician) (born 1963), mayor of Portland, Oregon
• Samuel Hunter Adams (1878–1975), mayor of Calgary, Alberta, Canada

• Samuel Adams (Loyalist) (1730–1810), Loyalist officer in the Revolutionary War, physician, surgeon
• Samuel Adams (naval officer) (1912–1942), United States naval officer
• Samuel A. Adams (1934–1988), CIA analyst known for challenging official enemy troop estimates during the Vietnam War

• Sam Adams (golfer) (born 1946), PGA Tour golfer
• Sam Adams Sr. (1948–2015), American football player
• Sam Adams (American football) (born 1973), American football player
• Sam Adams (Canadian football) (1928–2015), Canadian football player
• Sam Adams (footballer, born 1989), Ghanaian footballer

• Samuel Adams Sr. (1689–1748), American brewer
• Soren Sorensen Adams or Sam Adams (1879–1963), Danish-born American inventor of the Joy Buzzer and other novelties
• Sam Adams (explorer) (1828–1915), surveyor of the American West
• Samuel S. Adams (1937–2006), economic geologist
• Samuel Hopkins Adams (1871–1958), American writer and investigative journalist
• Samuel Adams (composer) (born 1985), American composer
• Sammy Adams (born 1987), American rapper
• Samuel Adams (priest) (1886–1856), Irish Anglican priest and Dean of Cashel
• Samuel B. Adams (1853–1938), Supreme Court of Georgia judge
• Samuel Hoppus Adams (1835–1895), British surgeon, physician and botanist

• Samuel Adams (beer), an American brand of beer
• Sam Adams Award

• Adams (surname)