Safra or SAFRA may refer to:

• Alberto J. Safra (born 1979/1980), Brazilian banker
• Edmond Safra (1932–1999), Syrian-Brazilian banker
• Jacob Safra (1891–1963), Syrian banker
• Jacqui Safra (born 1948), Swiss investor and actor
• Joseph Safra (1939–2020), Brazilian banker
• Lily Safra (1934–2022), Brazilian philanthropist and socialite
• Moise Safra (1934–2014), Brazilian businessman and philanthropist
• Rav Safra (280–338), Babylonian Amora
• Shmuel Safra, Israeli computer scientist
• Vicky Safra (born 1952/1953), Brazilian-born philanthropist

• Safra Catz (born 1961), American business executive

• Safra Group, an international network of companies controlled by the Joseph Safra family
  • Banco Safra
  • Bank Jacob Safra Switzerland
  • Safra National Bank of New York
• SAFRA Radio, a Singaporean broadcasting company
• SAFRA National Service Association, Singapore NSmen Recreation Club

• Safra, Iran, a village in Khuzestan Province, Iran
• Safra-ye Moqaddam, a village in Khuzestan Province, Iran
• Safra, Lebanon, a village in Lebanon
• Safra Square, Jerusalem's municipal plaza

• Battle of Al-Safra
• Student Aid and Fiscal Responsibility Act