Sackler is a surname. Notable people with the surname include:

• Arthur M. Sackler, American physician and pharmaceutical entrepreneur
• Elizabeth Sackler, American philanthropist
• Howard Sackler, American playwright (The Great White Hope)
• Mortimer Sackler, American pharmaceutical entrepreneur, brother to Arthur and Raymond
• Raymond Sackler, American pharmaceutical entrepreneur, brother to Mortimer and Arthur
• Richard Sackler (born 1945), American billionaire businessman, son of Raymond

• Sackler family, American family at the center of the opioid crisis known for founding and owning the pharmaceutical companies Purdue Pharma and Mundipharma
• Sackler Prize for theoretical physics
• Sackler Faculty of Medicine – in Tel Aviv, Israel
• Sackler Library – at Oxford University