Sack of Rome may refer to:

• Sack of Rome (390 BC) following the Battle of the Allia, by Brennus, king of the Senone Gauls
• Sack of Rome (410), by the Visigoths under Alaric I
• Sack of Rome (455), by the Vandals under Gaiseric
• Sack of Rome (546), by the Ostrogoths under King Totila
• Siege of Rome (549–550), also by Totila
• Sack of Rome (846), by the Arabs
• Sack of Rome (1084), by the adventurer Robert Guiscard's Normans
• Sack of Rome (1527), by mercenary troops of the Holy Roman Emperor Charles V

• The Sack of Rome, a 1920 Italian film depicting the 1527 event
• The Sack of Rome: How a Beautiful European Country with a Fabled History and a Storied Culture Was Taken Over by a Man Named Silvio Berlusconi, a book by Alexander Stille
• Le sac de Rome, an essay by Andre Chastel
• "Sack of Rome", a chess tournament victory by Sofia Polgar

• Battle for Rome (disambiguation)
• Battle of Rome (disambiguation)
• Capture of Rome
• Fall of Rome (disambiguation)
• Siege of Rome (disambiguation)