Steroidogenic acute regulatory protein is a protein that in humans is encoded by the STAR gene.
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Function
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].
Kim HJ, Kim JE, Ha M, Kang SS, Kim JT, Park IS, Paek SH, Jung HW, Kim DG, Cho GJ, Choi WS (July 2003). "Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors". Brain Res. 978 (1–2): 245–9. doi:10.1016/s0006-8993(03)02840-3. PMID12834921. S2CID32869169.
Kohen P, Castro O, Palomino A, Muñoz A, Christenson LK, Sierralta W, Carvallo P, Strauss JF, Devoto L (July 2003). "The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase". J. Clin. Endocrinol. Metab. 88 (7): 3421–30. doi:10.1210/jc.2002-021916. PMID12843197.