Protein-coding gene in the species Homo sapiens
Signal peptide peptidase-like 2A , also known as SPPL2A , is a human gene .[ 5]
Function This gene is a member of the signal peptide peptidase -like protease (SPPL) family and encodes a lysosomal/late endosomal membrane protein[ 6] TNFα in activated dendritic cells .[ 7] [ 8] [ 5]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000138600 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027366 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: SPPL2A signal peptide peptidase-like 2A" .^ Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B (2011). "Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail" . FEBS Letters . 585 (19): 2951– 7. doi :10.1016/j.febslet.2011.08.043 PMID 21896273 . ^ Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol . 8 (8): 843– 8. doi :10.1038/ncb1440 . PMID 16829952 . S2CID 129089 . ^ Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b" (PDF) . Nat. Cell Biol . 8 (8): 894– 6. doi :10.1038/ncb1450 . PMID 16829951 . S2CID 23712486 .
Further reading
Weihofen A, Binns K, Lemberg MK, et al. (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science . 296 (5576): 2215– 8. Bibcode :2002Sci...296.2215W . doi :10.1126/science.1070925 . PMID 12077416 . S2CID 45633906 . Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2002). "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc . 67 (7): 826– 35. doi :10.1023/A:1016365227942 . PMID 12139484 . S2CID 11785597 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes" . Nucleic Acids Res . 31 (7): 1877– 87. doi :10.1093/nar/gkg300 . PMC 152815 PMID 12655004 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins" . J. Biol. Chem . 279 (49): 50790– 8. doi :10.1074/jbc.M407898200 hdl :2262/89311 PMID 15385547 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117– 26. doi :10.1093/dnares/12.2.117 PMID 16303743 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55– 65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Kirkin V, Cahuzac N, Guardiola-Serrano F, et al. (2007). "The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells" . Cell Death Differ . 14 (9): 1678– 87. doi :10.1038/sj.cdd.4402175 PMID 17557115 .
