Protein-coding gene in the species Homo sapiens
Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene .[ 5] [ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000177045 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040841 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet . 4 (10): 1919– 25. doi :10.1093/hmg/4.10.1919 . PMID 8595416 . ^ "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)" .
Further reading
Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K (1999). "Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements" . Hum. Mol. Genet . 7 (13): 2103– 12. doi :10.1093/hmg/7.13.2103 PMID 9817928 . Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ (1999). "Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy" . Hum. Mol. Genet . 8 (3): 481– 92. doi :10.1093/hmg/8.3.481 PMID 9949207 . Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K (2000). "Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya" . Mol. Cell. Biol . 19 (10): 6815– 24. doi :10.1128/mcb.19.10.6815 . PMC 84678 PMID 10490620 . Harris SE, Winchester CL, Johnson KJ (2000). "Functional analysis of the homeodomain protein SIX5" . Nucleic Acids Res . 28 (9): 1871– 8. doi :10.1093/nar/28.9.1871 . PMC 103302 PMID 10756185 . Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M (2000). "Expression of a homeobox gene (SIX5) in borderline ovarian tumours" . J. Clin. Pathol . 53 (3): 212– 7. doi :10.1136/jcp.53.3.212 . PMC 1731149 PMID 10823141 . Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences" . J. Biol. Chem . 277 (9): 7021– 8. doi :10.1074/jbc.M108417200 hdl :10261/112516 PMID 11748221 . Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K (2002). "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1" . Hum. Mol. Genet . 11 (9): 1045– 58. doi :10.1093/hmg/11.9.1045 PMID 11978764 . Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". J. Muscle Res. Cell. Motil . 23 (3): 255– 64. doi :10.1023/A:1020990825644 . PMID 12500905 . S2CID 42497614 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801– 14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F (2007). "Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome" . Am. J. Hum. Genet . 80 (4): 800– 4. doi :10.1086/513322 . PMC 1852719 PMID 17357085 .
External links
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
