Protein-coding gene in the species Homo sapiens
Protein SET , also known as Protein SET 1 , is a protein that in humans is encoded by the SET gene .[ 5] [ 6] [ 7]
Interactions Protein SET has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000119335 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054766 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene" . Molecular and Cellular Biology . 12 (8): 3346– 55. doi :10.1128/mcb.12.8.3346 . PMC 364582 PMID 1630450 . ^ Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A" . The Journal of Biological Chemistry . 271 (19): 11059– 62. doi :10.1074/jbc.271.19.11059 PMID 8626647 . ^ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)" .^ a b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein" . Cell . 104 (1): 119– 30. doi :10.1016/s0092-8674(01)00196-9 PMID 11163245 . S2CID 11144887 . ^ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A" . Molecular and Cellular Biology . 22 (8): 2810– 20. doi :10.1128/mcb.22.8.2810-2820.2002 . PMC 133744 PMID 11909973 . ^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity" . The Journal of Biological Chemistry . 277 (9): 7324– 32. doi :10.1074/jbc.M107270200 hdl :10536/DRO/DU:30101408 PMID 11741927 . ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain" . Molecular and Cellular Biology . 23 (23): 8528– 41. doi :10.1128/mcb.23.23.8528-8541.2003 . PMC 262669 PMID 14612398 . ^ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor" . Cell . 112 (5): 659– 72. doi :10.1016/s0092-8674(03)00150-8 PMID 12628186 . S2CID 14019153 .
Further reading
Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis" . Proceedings of the National Academy of Sciences of the United States of America . 92 (10): 4279– 83. Bibcode :1995PNAS...92.4279N . doi :10.1073/pnas.92.10.4279 PMC 41927 PMID 7753797 . Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1– 2): 171– 4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia" . FEBS Letters . 340 (3): 231– 5. Bibcode :1994FEBSL.340..231A . doi :10.1016/0014-5793(94)80144-4 PMID 8131851 . S2CID 36974869 . Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler . 375 (2): 113– 26. doi :10.1515/bchm3.1994.375.2.113 . PMID 8192856 . Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia" . The Journal of Biological Chemistry . 269 (3): 2258– 62. doi :10.1016/S0021-9258(17)42162-4 PMID 8294483 . Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A" . The Journal of Biological Chemistry . 272 (45): 28407– 14. doi :10.1074/jbc.272.45.28407 PMID 9353299 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1– 2): 149– 56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor" . Journal of the American Society of Nephrology . 9 (10): 1873– 80. doi :10.1681/ASN.V9101873 PMID 9773788 . Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo" . The Journal of Cell Biology . 151 (1): 1– 14. doi :10.1083/jcb.151.1.1 . PMC 2189805 PMID 11018049 . Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators" . Molecular and Cellular Biology . 20 (23): 8933– 43. doi :10.1128/MCB.20.23.8933-8943.2000 . PMC 86548 PMID 11073993 . Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788– 95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein" . Cell . 104 (1): 119– 30. doi :10.1016/S0092-8674(01)00196-9 PMID 11163245 . S2CID 11144887 . Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET" (PDF) . European Journal of Biochemistry . 268 (5): 1340– 51. doi :10.1046/j.1432-1327.2001.02000.x hdl :2433/150179 . PMID 11231286 . Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks" . The Journal of Biological Chemistry . 276 (46): 43285– 93. doi :10.1074/jbc.M108137200 PMID 11555662 . Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity" . The Journal of Biological Chemistry . 277 (9): 7324– 32. doi :10.1074/jbc.M107270200 hdl :10536/DRO/DU:30101408 PMID 11741927 . Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A" . Molecular and Cellular Biology . 22 (8): 2810– 20. doi :10.1128/MCB.22.8.2810-2820.2002 . PMC 133744 PMID 11909973 . Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing" . The Journal of Biological Chemistry . 277 (28): 25026– 31. doi :10.1074/jbc.M202256200 PMID 11978794 .
