SC-44 may refer to:

• Siemens SC-44, the first production model of the Siemens Charger locomotive.
• Honda SC44, a motorcycle, a model of the Honda CBR900RR-series
• USS SC-44, a United States Navy submarine chaser commissioned in 1918 and sold in 1921.
• South Carolina Highway 44 (disambiguation) (SC-44), several highways in the United States

• Scandium-44 (Sc-44), an isotope of the chemical element Scandium.

• All pages with titles containing SC-44
• All pages with titles containing SC44