S. Ramachandran may refer to:

• S. Ramachandran (filmmaker), Indian film journalist and director
• S. Ramachandran (scientist) (1934–2016), Indian biotechnologist
• S. M. Ramachandran, Indian politician in Tamil Nadu
• Srinivasan Ramachandran, Indian bioinformatician
• Subramaniam Ramachandran, missing Sri Lankan Tamil journalist
• N. S. Ramachandran (1908–?), Indian composer of Carnatic music
• Panruti S. Ramachandran (born 1937), Indian politician in Tamil Nadu
• V. S. Ramachandran (born 1951), Indian-American neuroscientist
• S. Ramachandran Pillai (born 1938), Indian communist politician from Kerala