Rourke is a surname. Notable people with the surname include:

• Allan Rourke (b. 1980), Canadian professional ice hockey player
• Andy Rourke (1964–2023), English bass guitarist
• Colin P. Rourke (b. 1943), British mathematician
• Constance Rourke (1885–1941), American author and educator
• James Rourke (1838–1914), Canadian lumber manufacturer and politician from New Brunswick
• John Patrick Rourke (b. 1942), South African botanist
• Josie Rourke (b. 1976), British theatrical director
• Kurtis Rourke (b. 2000), Canadian player of American football (brother of Nathan)
• Mickey Rourke (b. 1952), American film actor
• Nathan Rourke (b. 1998), Canadian professional football player (brother of Kurtis)
• Russell A. Rourke (1931–2003), American government administrator; Secretary of the Air Force 1985–86

• Dorothy Ann Rourke, one of the central characters of The Magic School Bus
• Jack Rourke, protagonist of the 2011 video game Need for Speed: The Run
• Lyle Tiberius Rourke, main antagonist of the 2001 Disney film, Atlantis: The Lost Empire, voiced by James Garner

• O'Rourke
• O'Rorke
• Roarke