Rio Claro (Portuguese and Spanish for "clear river" or "clean river") may refer to:

• Rio Claro, Trinidad and Tobago, the largest town in southeastern Trinidad and Tobago
• Rio Claro, Rio de Janeiro, a Brazilian municipality in the state of Rio de Janeiro
• Rio Claro, São Paulo, a Brazilian municipality in the state of São Paulo
• Rio Claro, Costa Rica, a small Costa Rican city located in the province of Puntarenas in the southwestern region of the country, near the border with Panama
• Río Claro, a commune of the Talca Province, Maule Region, Chile

• Claro River (Bolivia)

• Claro River (Apucaraninha River)
• Claro River (Araguaia River)
• Claro River (Iguazu River)
• Claro River (Ivaí River)
• Claro River (lower Tietê River)
• Claro River (Minas Gerais)
• Claro River (Paranaíba River)
• Claro River (Pardo River)
• Claro River (Preto River)
• Claro River (upper Tietê River)

• Claro River (Elqui) tributary of the Elqui River in the Coquimbo Region
• Claro River (Tinguiririca) a tributary of the Tinguiririca River in the O'Higgins Region
• Claro River (Teno) a tributary of the Teno River in the Maule Region
• Claro River (Maule) a tributary of the Maule River in the Maule Region
• Claro River (Laja) a tributary of the Laja River in the Bío-Bío Region

• Claro River (Costa Rica), a river of Costa Rica

• Claro River (Trinidad and Tobago)

• Rio Claro Futebol Clube, a Brazilian football (soccer) club

• River Clare, Ireland