R. J. Reynolds Tobacco Company is an American tobacco company.

RJR may also refer to:

• RJR-MacDonald Inc v Canada (AG), a Supreme Court of Canada case involving the tobacco company
• RJR Nabisco, from which the tobacco company was split
• RJR-2429 a drug that acts as an agonist at neural nicotinic acetylcholine receptors
• RJR 94 FM, a broadcast company in Jamaica
• RJR Airdrome, Inc., owner of Chandelle Estates Airport in Delaware