Perotti is an Italian surname. Notable people with the surname include:

• Angelica Le Gru Perotti (1719–1776), Italian painter
• Diego Perotti (born 1988), Argentine footballer
• Fulvia Miani Perotti (1844–1931), Italian writer
• Giovanni Domenico Perotti (1761–1825), Italian composer
• José Perotti Ronzoni (1898–1956), Chilean sculptor
• Juan Perotti (born 1992), Argentine footballer
• Niccolò Perotti (1429–1480), Italian humanist and author
• Omar Perotti (born 1959), Argentine politician