Paganelli is an Italian surname, and may refer to;

• Carl Paganelli (b. 1960), American football official in the National Football League
• Domenico Paganelli, Italian architect
• Giuseppe Antonio Paganelli, Italian singer and composer
• Laurent Paganelli (b. 1962), French former footballer
• Manuello Paganelli (b. 1960), American artist and photographer
• Mirco Paganelli, Italian former footballer
• Niccolò Paganelli (1538–1620), Italian painter
• Pietro dei Paganelli di Montemagno (1080–1153), later became Pope Eugene III
• Umberto Paganelli, Italian artistic roller skating

• Paganini (disambiguation)

• L'Italia dei cognomi Gens.labo.net
• Dissemination of the surname PAGANELLI in Italy