Protein-coding gene in the species Homo sapiens
PPP3CA Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI , 1M63 , 1MF8 , 2JOG , 2JZI , 2P6B , 2R28 , 2W73 , 3LL8 , 4F0Z , 4Q5U , 5C1V
Identifiers Aliases PPP3CA External IDs OMIM : 114105 ; MGI : 107164 ; HomoloGene : 55497 ; GeneCards : PPP3CA ; OMA :PPP3CA - orthologs Wikidata
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA ) is a protein that in humans is encoded by the PPP3CA gene .[ 5] [ 6]
References
Further reading
Crabtree GR (March 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT" . Cell . 96 (5): 611– 4. doi :10.1016/S0092-8674(00)80571-1 PMID 10089876 . S2CID 8817053 . Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (April 1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science . 284 (5412): 339– 43. Bibcode :1999Sci...284..339W . doi :10.1126/science.284.5412.339 . PMID 10195903 . Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S (July 2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways" . Human Molecular Genetics . 9 (11): 1681– 90. doi :10.1093/hmg/9.11.1681 PMID 10861295 . Frey N, Richardson JA, Olson EN (December 2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14632– 7. Bibcode :2000PNAS...9714632F . doi :10.1073/pnas.260501097 PMC 18970 PMID 11114196 . Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y (May 2001). "Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism" . Endocrinology . 142 (5): 1752– 9. doi :10.1210/endo.142.5.8156 PMID 11316738 . Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (June 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature" . Cell . 105 (7): 863– 75. doi :10.1016/S0092-8674(01)00396-8 PMID 11439183 . S2CID 5278706 . Mukerjee N, McGinnis KM, Gnegy ME, Wang KK (August 2001). "Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation". Biochemical and Biophysical Research Communications . 285 (5): 1192– 9. CiteSeerX 10.1.1.414.4108 doi :10.1006/bbrc.2001.5278 . PMID 11478781 . Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A (August 2001). "Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin" . FEBS Letters . 503 (2– 3): 201– 5. doi :10.1016/S0014-5793(01)02730-2 PMID 11513882 . S2CID 44432580 . Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (November 2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells" . The Journal of Experimental Medicine . 194 (10): 1449– 59. doi :10.1084/jem.194.10.1449 . PMC 2193671 PMID 11714752 . Frey N, Olson EN (April 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins" . The Journal of Biological Chemistry . 277 (16): 13998– 4004. doi :10.1074/jbc.M200712200 PMID 11842093 .
