Protein-coding gene in the species Homo sapiens
Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene .[ 5] [ 6] [ 7]
Function Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins .[ 8] [ 9]
Interactions PLXNB1 has been shown to interact with ARHGEF12 ,[ 10] Rnd1 [ 11] ARHGEF11 .[ 10] [ 11] [ 12] [ 13]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000164050 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053646 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor" . Proc Natl Acad Sci U S A . 93 (2): 674–8. Bibcode :1996PNAS...93..674M . doi :10.1073/pnas.93.2.674 PMC 40111 PMID 8570614 . ^ Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner" . Proc Natl Acad Sci U S A . 97 (23): 12457–62. Bibcode :2000PNAS...9712457V . doi :10.1073/pnas.220421797 PMC 18785 PMID 11035813 . ^ "Entrez Gene: PLXNB1 plexin B1" .^ Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF" . FEBS Letters . 529 (2–3): 168–72. doi :10.1016/s0014-5793(02)03323-9 PMID 12372594 . S2CID 26525009 . ^ Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway" . Molecular and Cellular Biology . 25 (16): 6889–98. doi :10.1128/mcb.25.16.6889-6898.2005 . PMC 1190270 PMID 16055703 . ^ a b Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun . 297 (1): 32–7. doi :10.1016/S0006-291X(02)02122-8 . PMID 12220504 . ^ a b Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells" . J. Biol. Chem . 278 (28): 25671–7. doi :10.1074/jbc.M303047200 PMID 12730235 . ^ Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF" . J. Biol. Chem . 277 (45): 43115–20. doi :10.1074/jbc.M206005200 PMID 12183458 . ^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology" . Neuron . 35 (1): 51–63. doi :10.1016/S0896-6273(02)00750-X PMID 12123608 . S2CID 18981429 . Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87; doi :10.4049/immunohorizons.1800026
Further reading
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 4 (5): 307–13. doi :10.1093/dnares/4.5.307 PMID 9455477 . Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates" . Cell . 99 (1): 71–80. doi :10.1016/S0092-8674(00)80063-X PMID 10520995 . S2CID 17386412 . Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding" . Genes Dev . 16 (7): 836–45. doi :10.1101/gad.966402 . PMC 186329 PMID 11937491 . Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology" . Neuron . 35 (1): 51–63. doi :10.1016/S0896-6273(02)00750-X PMID 12123608 . S2CID 18981429 . Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF" . J. Biol. Chem . 277 (45): 43115–20. doi :10.1074/jbc.M206005200 PMID 12183458 . Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG" . Proc. Natl. Acad. Sci. U.S.A . 99 (19): 12085–90. Bibcode :2002PNAS...9912085A . doi :10.1073/pnas.142433199 PMC 129402 PMID 12196628 . Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol . 4 (9): 720–4. doi :10.1038/ncb843 . PMID 12198496 . S2CID 130071 . Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun . 297 (1): 32–7. doi :10.1016/S0006-291X(02)02122-8 . PMID 12220504 . Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes" . Blood . 101 (5): 1962–9. doi :10.1182/blood-2002-05-1339 PMID 12406905 . Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases" . J. Biol. Chem . 278 (12): 10094–101. doi :10.1074/jbc.M210156200 PMID 12533544 . Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun . 300 (4): 927–31. doi :10.1016/S0006-291X(02)02966-2 . PMID 12559962 . Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells" . J. Biol. Chem . 278 (28): 25671–7. doi :10.1074/jbc.M303047200 PMID 12730235 . Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene . 23 (30): 5131–7. doi :10.1038/sj.onc.1207650 . PMID 15184888 . S2CID 24596233 . Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2" . J. Cell Biol . 165 (6): 869–80. doi :10.1083/jcb.200312094 . PMC 2172401 PMID 15210733 . Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science . 305 (5685): 862–5. Bibcode :2004Sci...305..862O . doi :10.1126/science.1097545 . PMID 15297673 . S2CID 39544623 . Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1" . Blood . 105 (11): 4321–9. doi :10.1182/blood-2004-07-2885 PMID 15632204 .
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