Protein-coding gene in the species Homo sapiens
PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene .[ 5] [ 6]
An important paralog of this gene is PKNOX2 .
Function PKNOX1 belongs to the three amino acid loop extension (TALE) class of homeodomain transcription factors that form transcriptionally active complexes involved in development and organogenesis . PKNOX1 is essential for embryogenesis , but it can also act as a tumor suppressor in adulthood .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000160199 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006705 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (January 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics . 47 (2): 323– 4. doi :10.1006/geno.1997.5086 . PMID 9479508 .
^ "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1" . Archived from the original on 2010-12-05. Retrieved 2017-09-07 .
^ Purushothaman D, Blasi F (2018). "The genetics and the molecular functions of the PREP1 homeodomain transcription factor" . The International Journal of Developmental Biology . 62 (11– 12): 819– 825. doi :10.1387/ijdb.180238fb . PMID 30604851 .
Further reading
Allen TD, Zhu YX, Hawley TS, Hawley RG (October 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma . 39 (3– 4): 241– 56. doi :10.3109/10428190009065824 . PMID 11342305 . S2CID 27407074 .
Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins" . Genes & Development . 9 (6): 663– 74. doi :10.1101/gad.9.6.663 . PMID 7729685 .
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1– 2): 171– 4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags" . Genome Research . 6 (9): 807– 28. doi :10.1101/gr.6.9.807 . PMID 8889549 .
Phelan ML, Featherstone MS (March 1997). "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers" . The Journal of Biological Chemistry . 272 (13): 8635– 43. doi :10.1074/jbc.272.13.8635 . PMID 9079695 .
Chen H, Rossier C, Nakamura Y, Lynn A, Chakravarti A, Antonarakis SE (April 1997). "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3". Genomics . 41 (2): 193– 200. doi :10.1006/geno.1997.4632 . PMID 9143494 .
LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (October 1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains" . Oncogene . 15 (17): 2059– 67. doi :10.1038/sj.onc.1201367 . PMID 9366523 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1– 2): 149– 56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Berthelsen J, Zappavigna V, Mavilio F, Blasi F (March 1998). "Prep1, a novel functional partner of Pbx proteins" . The EMBO Journal . 17 (5): 1423– 33. doi :10.1093/emboj/17.5.1423 . PMC 1170490 . PMID 9482739 .
Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (March 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity" . The EMBO Journal . 17 (5): 1434– 45. doi :10.1093/emboj/17.5.1434 . PMC 1170491 . PMID 9482740 .
Green NC, Rambaldi I, Teakles J, Featherstone MS (May 1998). "A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1" . The Journal of Biological Chemistry . 273 (21): 13273– 9. doi :10.1074/jbc.273.21.13273 . PMID 9582372 .
Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F, Zappavigna V (April 1999). "The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH" . Genes & Development . 13 (8): 946– 53. doi :10.1101/gad.13.8.946 . PMC 316640 . PMID 10215622 .
Jacobs Y, Schnabel CA, Cleary ML (July 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity" . Molecular and Cellular Biology . 19 (7): 5134– 42. doi :10.1128/mcb.19.7.5134 . PMC 84356 . PMID 10373562 .
Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, et al. (September 1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1" . Nucleic Acids Research . 27 (18): 3752– 61. doi :10.1093/nar/27.18.3752 . PMC 148632 . PMID 10471746 .
Kömüves LG, Shen WF, Kwong A, Stelnicki E, Rozenfeld S, Oda Y, et al. (August 2000). "Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation" . Developmental Dynamics . 218 (4): 636– 47. doi :10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I . PMID 10906782 .
Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I, Doi T (May 2003). "PREP1, MEIS1 homolog protein, regulates PF4 gene expression". Biochemical and Biophysical Research Communications . 305 (1): 155– 9. doi :10.1016/S0006-291X(03)00718-6 . PMID 12732210 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors