P22 may refer to:

• P22 (type foundry), a digital type foundry, Rochester, New York, United States
• LÉ Aoife (P22), a patrol vessel of the Irish Naval Service
• Curtiss XP-22 Hawk, an experimental biplane fighter
• Maltese patrol boat P22, of the Armed Forces of Malta
• Mwera language
• Papyrus 22, a biblical manuscript
• Salmonella virus P22, a bacteriophage
• Walther P22, a pistol
• Norfolk Southern train P22, involved in the 2005 Graniteville train crash, South Carolina, United States
• P22, a state regional road in Latvia
• P-22, a mountain lion that resided in Griffith Park, Los Angeles, California, United States