Orange Book may refer to:

• Trusted Computer System Evaluation Criteria, a computer security standard
• We Can Conquer Unemployment, 1929 manifesto by David Lloyd George and the Liberal Party
• The Orange Book: Reclaiming Liberalism, by members of the British Liberal Democrat party
• Approved Drug Products with Therapeutic Equivalence Evaluations, published by the FDA's Center for Drug Evaluation and Research
• The IUPAC Compendium of Analytical Nomenclature informally known as the Orange Book
• One of the compact disc standards collections in the Rainbow Books series
• Orange-Book-Standard, issued in 2009 by the German Federal Court of Justice on the interaction between patent law and standards
• Orange Book, a local area networking protocol based on the Cambridge Ring and one of the UK Coloured Book protocols
• Handbook of Directives and Permitted Conventions for the English Bridge Union
• A book about OpenGL Shading Language
• The Orange Book, volume 2 (1970) of the British series Carols for Choirs

• The Orange Box
• Black Book (disambiguation)
• Blue book (disambiguation)
• Green Book (disambiguation)
• Pink Book (disambiguation)
• Plum Book
• White book (disambiguation)
• Yellow Book (disambiguation)