One Tree Hill may refer to:

• "One Tree Hill" (song), a 1987 song by U2 referencing One Tree Hill, New Zealand volcanic peak
• One Tree Hill (TV series), a 2003–2012 American drama series named for the U2 song
  • One Tree Hill (soundtrack), a 2005 soundtrack album from the series

• One Tree Hill (Australian Capital Territory), a peak on the ACT-NSW border, near Hall
• One Tree Hill (Blue Mountains), a peak at Mount Victoria in the Blue Mountains of New South Wales
• One Tree Hill, Ferntree Gully in the Dandenong Ranges National Park, Victoria
• One Tree Hill, South Australia, a suburb on the northern outskirts of Adelaide, South Australia
• One Tree Hill, former name of Mount Coot-tha, Queensland, in Brisbane
• One Tree Hill, former name of Table Top Mountain near Toowoomba, Queensland
  • Site of the Battle of One Tree Hill (1843), Queensland

• One Tree Hill Point, a location in Matheran Hill Station near Mumbai

• Maungakiekie / One Tree Hill, a volcanic peak in Auckland
• One Tree Hill, New Zealand, a suburb in Auckland at the base of the volcanic peak
• One Tree Hill College, Auckland

• One Tree Hill, Sri Lanka, a hill in the Nuwara Eliya District

• One Tree Hill Country Park in Basildon, Essex
• One Tree Hill, Honor Oak, in London

• One Tree Hill, a codename of the Mozilla Firefox 0.9 release

• Tree Hill (disambiguation)