Old Dominion most commonly refers to:

• The Old Dominion, a nickname for the U.S. Commonwealth of Virginia
  • Colony of Virginia
• Old Dominion University, a public university in Norfolk, Virginia
  • Old Dominion Monarchs, the athletic teams representing Old Dominion University
• Old Dominion, Virginia, an unincorporated community in Albemarle County, Virginia

Old Dominion may also refer to:

• Old Dominion (band), an American country-rock band
  • Old Dominion (EP)
  • Old Dominion (album)
• Old Dominion, an album by Hotel of the Laughing Tree
• "Old Dominion", a 2000 song by Avail from One Wrench
• "Old Dominion", a 2002 song by Enon from lavrage

• Old Dominion (train), a former Amtrak passenger train in the United States
• Old Dominion Athletic Conference, an NCAA Division III athletic conference
• Old Dominion Brewing Company
• Old Dominion Electric Cooperative
• Old Dominion Foundation, a predecessor of the Andrew W. Mellon Foundation
• Old Dominion Freight Line
• Old Dominion (magazine), a magazine from 1870 to 1873