Oh! Susanna may refer to:

• "Oh! Susanna", a song written by Stephen Foster in 1847
• Suzie Ungerleider, a Canadian singer who formerly performed as Oh Susanna
• The Gale Storm Show, a television series known in syndication as Oh, Susanna
• Oh Susanna, a Canadian improvisation variety show
• Oh! Susanna (1951 film), a 1951 Western film starring Rod Cameron
• Oh, Susanna! (1936 film), a Western film directed by Joseph Kane
• Oh, Susannah!, a 1982 novel by Kate Wilhelm
• Oh! Susannah!, an 1897 comedy play by Mark Ambient