Never Say Die may refer to:

• Never Say Die (memoir), a 1961 memoir by Jack Hawkins
• Never Say Die (novel), a 2017 novel in the Alex Rider series by Anthony Horowitz

• Never Say Die (1920 film), British film by Walter Forde
• Never Say Die (1924 film), a film featuring Douglas MacLean
• Never Say Die (1939 film), a romantic comedy starring Bob Hope and Martha Raye
• Never Say Die (1950 film), or Don't Say Die, British comedy film
• Never Say Die (1988 film), a New Zealand action film
• Never Say Die (2017 film), a Chinese film
• Never Say Die (TV series), a 1970 British comedy television series produced by Yorkshire Television
• "Never Say Die", an episode of the TV series Diagnosis: Murder

• Never Say Die! Tour (Black Sabbath), a 1978 tour by Black Sabbath
• Impericon Never Say Die! Tour, an annual European metalcore musical tour

• Never Say Die!, a 1978 album by Black Sabbath, or the title song
  • Never Say Die (video), a 1986 video by Black Sabbath
• Never Say Die (Petra album), 1981
• Never Say Die: Live, a 2000 album by Waylon Jennings & The Waymore Blues Band, or the title song
  • Never Say Die: The Final Concert, a 2000 concert film featuring Waylon Jennings
• Never Say Die, an album by The Undead, or the title song
• Never Say Die (Wig Wam album), a 2021 album by Wig Wam, or the title song

• "Never Say Die" (Chvrches song). 2018
• "Never Say Die" (Jon Bon Jovi song), 1991
• "Never Say Die" (The 69 Eyes song), 2007
• "It's All Too Much"/"Never Say Die", a 2009 single by Yui
• "Never Say Die", a song by Europe from Out of This World
• "Never Say Die", a song by Marianas Trench from Astoria
• "Never Say Die", a song by the Monkey Hangerz on the single "Poolie Pride"
• "Never Say Die", a song by Sleigh Bells from Reign of Terror
• "Never Say Die (Give a Little Bit More)", a 1983 song by Cliff Richard

• Never Say Die (horse) (1951–1975), Thoroughbred racehorse