Negrão is a surname. Notable people with the surname include:

• Alexandre Sarnes Negrão (born 1985), Brazilian entrepreneur and race car driver
• André Negrão (born 1992), Brazilian racing driver
• Fernando Negrão (born 1955), Portuguese jurist and politician
• Júnior Negrão (born 1986), Brazilian footballer
• Marcelo Negrão (born 1972), Brazilian volleyball player
• Mário Negrão (born 1945), Brazilian composer, drummer and percussionist