N59 follows a route that runs from Antipolo to Cainta in Rizal, entering Metro Manila through Pasig, then Marikina towards Quezon City. The highway connects most major regional centers and runs through different landscapes. It continues westward as the N180 highway and eastward as the N600 highway.
N59 begins at Antipolo in Rizal at the endpoint of L. Sumulong Memorial Circle Road (N600) in front of Robinsons Place Antipolo. The highway passes through different key locations at Antipolo, which is known for its scenic views of Metro Manila, given its mountainous terrain. The roadway goes downward until it meets with the Marikina-Infanta Highway at the Masinag Junction, where the N59 route turns left.
As soon as it turns left, the highway soon enters the Marikina–Infanta Highway (Marcos Highway), where it follows the LRT Line 2 from Masinag Junction, Antipolo, Rizal, where it begins on a straight route as it crosses over to Cainta. N59 enters Metro Manila in Pasig and Marikina at the Felix Avenue and Gil Fernando Avenue intersection. N59 then crosses the Marikina River, veering upwards in a curve towards its junction with A. Bonifacio Avenue. It then enters Quezon City before terminating at C-5/Katipunan Avenue (N11) and Aurora Boulevard (N59) intersection. The LRT Line 2 utilizes the center island of Marikina-Infanta Highway on all segments of N59.
Entering Quezon City, N59 follows Aurora Boulevard, which runs on a four- to six-lane highway passing through intersections such as Anonas Street in Project 3, 20th Avenue in Project 4, and Araneta City streets in Cubao. It then terminates at its intersection with EDSA (N1/AH26), continuing westward after the intersection as N180 highway but still as Aurora Boulevard. The LRT Line 2 utilizes the center island of Aurora Boulevard on all segments.
N600 in Antipolo, Rizal
AH 26 (N1) / N180 in Quezon City
