Mohammad Ayub may refer to:

• Mohammad Ayub Khan (1907–1974), Pakistani general and president
• Mohammad Ayub (cricketer, born 1965), Indian cricketer
• Mohammad Ayub (Bagram captive 2006, son of Mohammad Usman), listed on a habeas petition, see List of Bagram captives
• Mohammed Ayub (born 1984), a Uyghur, formerly held in the Guantanamo Bay detention camps, in Cuba
• Mohammed Ayub (Bagram captive 2006, son of Kareem Khan), listed on a habeas petition, see List of Bagram captives
• Mohammad Ayub (Pakistani cricketer) (born 1979), Pakistani cricketer
• Master Ayub, Pakistani teacher who runs an open air, free of cost, school in Islamabad since 1986