Mikhail Popov may refer to:

• Mikhail Abramovich Popov (1753–1811), Russian businessman and politician, first mayor of Perm
• Mikhail Ivanovich Popov (1742–1790), Russian writer and poet
• Mikhail Grigorevich Popov (1893–1955), Russian botanist
• Mikhail Yuryevich Popov (born 1985), Russian footballer
• Mikhail Popov (athlete), Paralympic athlete from Russia
• Mihail Popov, (born 1976) Bulgarian and French badminton player
• Major General Mikhail Popov, (born 1963) Commander of the Bulgarian Land Forces
• Mikhail Vasilyevich Popov