Michael Byrne may refer to:

• Michael Byrne (actor) (born 1943), English actor
• Michael Byrne (poet) (born 1978), Australian poet
• Mike Byrne (guitarist), American guitarist for The Methadones
• Mike Byrne (musician) (born 1990), American drummer with Smashing Pumpkins
• Michael Byrne (artist) (1923–1989), Irish painter

• Mick Byrne (Australian footballer) (born 1958), Australian rules footballer
• Michael Byrne (baseball) (born 1997), American baseball pitcher
• Michael Byrne (footballer, born 1880) (1880–1931), English-born Irish footballer with Chelsea, Southampton and Glossop
• Michael Byrne (footballer, born 1985), English-born Welsh footballer playing for Chainat
• Michael Byrne (gridiron football) (born 1986), American football offensive lineman
• Michael Byrne (hurler) (born 1978), Irish hurler
• Mick Byrne (Irish footballer) (born 1960), Irish footballer
• Mickey Byrne (1923–2016), Irish hurler

• Michael Byrne (sailor) (1761–after 1792), born in Kilkenny, Ireland
• Michael J. Byrne (1941–2020), Australian oncologist

• Micky Burn (1912–2010), English journalist
• Michael Burns (disambiguation)