The 20 chosen semi-finalists converged on Puebla's La Purificadora hotel for casting week, where they met the judges for interviews and took part in a photo shoot where they had to portray angels. At the end of the episode, the judges selected the final 13.

The contestants moved into their new home in Mexico City, and were later taken to meet Sears representative Edgar Smolensky for a styling challenge, which was won by Cecilia. The models later posed as dog walkers wearing lingerie for the photo shoot, and at elimination, Kathya became the first contestant to leave the competition.

• Featured photographer: Tito Trueba
• Special guests: Edgar Smolensky, Mauricio Olvera

The contestants were introduced to MAC representative Jorge Rios, and had a make-up challenge, which was won by Verónica. They later received makeovers, and had a colorful fabric photo shoot in pairs. At elimination, Yatzil became the second contestant to leave the competition.

• Featured photographer: David Franco
• Special guests: Jorge Rios, Alex Lopex, Desiré Navarro

The contestants received a runway lesson at the circus, and had a runway challenge later that night. Cecilia was deemed as the best performer, winning a feature in Glamour magazine. At the photo shoot the models were given colorful styling and hung upside down, with the final shots being judged right-side up. At elimination, Isabel became the third contestant to leave the competition.

• Featured photographer: Tito Trueba
• Special guests: JLo, Paulina Flores

The remaining ten contestants visited the Etro boutique in Polanco for a posing lesson with boutique owner Andrea Ororica, and had a posing challenge as window display mannequins, which was won by Nohemí. They later posed as couture interpretations of la Catrina. At elimination, Fernanda became the fourth contestant to leave the competition.

• Featured photographer: Edgar Ladrón de Guevara
• Special guests: Andrea Ororica

The contestants were taken to the Anahuacalli Museum to practice their emoting for a challenge in which they had to portray six different emotions for a series of photos, where Silvia, Paulina, and Nohemí were chosen as the winners. At the photo shoot, the models had to pose as criminals getting their mugshots taken, with each contestant portraying a different character. At elimination, Ana Laura became the fifth contestant to leave the competition.

• Featured photographer: David Franco
• Special guests: Paulina Flores

The contestants were taken to the offices of Shock Modeling management to meet agency director Estela Saenz for a go-sees challenge with designers around the city, at the end of which Paulina, Verónica, Nohemí, and Andrea were chosen as the winners. The models later arrived at the Naucalpan Arena for a photo shoot where they were styled in glamorous outfits while wrestlers fought in the background. At elimination, Silvia became the sixth contestant to leave the competition.

• Featured photographer: Hermanos Clint
• Special guests: Estela Saenz, Mauricio Olvera

The contestants met commercial director Freddy Garza for a workshop, before being introduced to actor and RBD band member Alfonso Herrera for an acting challenge, which was won by Cecilia. The models later shot a commercial for Sedal, under the direction of Mario Muñoz. At elimination, Anelís became the seventh contestant to leave from the competition.

• Featured director: Mario Muñoz
• Special guests: Freddy Garza, Alfonso Herrera, Mario Muñoz, Laura Ramirez

The contestants had a challenge in which they had to learn the skills of communication between a photographer and model by taking photos of one another, where Paulina was chosen as the winner. The models later had a photo shoot, with male model Guillerme Casali, in which they had to portray a couple stuck on the side of the road, and found out that they would be getting their photos taken by America's Next Top Model judge Nigel Barker. At elimination, Verónica became the eighth contestant to leave the competition.

• Featured photographer: Nigel Barker
• Special guests: Aislinn Derbez, Guilherme Casali

The remaining contestants met the director of Glamour magazine, Mar Abascal, and had a runway challenge on top of a bar counter where Cecilia was deemed as the best performer, winning a photo shoot session with judge Allan Fis. The models later met photographer Gregory Allen for a photo shoot where they posed with actor Erick Elías, to portray famous Telenovela posters. At elimination, Andrea became the ninth contestant to leave the competition.

• Featured photographer: Gregory Allen
• Special guests: Dinora Cetina, Mar Abascal, Erick Elías,

The contestants met TV presenter Rebecca de Alba for a lesson on dealing with the press, as well as maintaining their self-esteem while competing with other models in the industry. They were then taken for an interview challenge with Candela Ferro, which was won by Cecilia, who was given half of Mariana's frames for the next photo shoot. The models later visited the Frida Kahlo Museum, where they posed in a composite photo shoot dressed as Frida Kahlo painting a self-portrait. At eliminaton, Paulina became the tenth contestant to be eliminated from the competition, leaving Cecilia, Mariana, and Nohemí as the three remaining finalists.

• Featured photographer: Ivan Aguirre
• Special guests: Rebecca de Alba, Candela Ferro

The final three traveled to Ixtapa, where they shot a commercial for Sedal, before having their photos taken in a trampoline photo shoot, after which Cecilia was eliminated. The remaining two contestants, Mariana and Nohemí, took part in a final runway show. After the final deliberation, Mariana was crowned as the first winner of Mexico's Next Top Model.

• Featured photographer: Alan Fis