Mercurio may refer to:

• Mercurio Martinez (born 1937), Texas politician; see Laredo College
• Angelo Mercurio (1936–2006), Italian-American mobster
• Gus Mercurio (1928–2010), American-born Australian character actor
• Jed Mercurio (born 1966), British writer
• Paul Mercurio (born 1963), Australian actor and dancer
• Steven Mercurio, American composer and conductor
• Mercurio (wrestler), the ring name of a Mexican professional wrestler

• El Mercurio, a Chilean newspaper
• El Mercurio de Valparaíso, another Chilean newspaper
• El Mercurio (Ecuador), an Ecuadorian newspaper

• Mercurio the 4-D Man, a fictional character that appears in the Marvel Universe
• Mercurio (album), of 2013 by Italian rapper Emis Killa
• "Mercurio", a song by Karol G from Mañana Será Bonito, 2023

• Mercury (disambiguation)