Melnychuk is Ukrainian surname and a patronymic derivative of Melnyk. Alternative spellings: via Russian: Melnichuk, via Polish: Melniczuk/Melnyczuk. Notable people with the surname include:

• Alexei Melnichuk, Russian ice hockey player
• Askold Melnyczuk, American writer
• Dmytro Melnychuk (born 1943), Ukrainian scientist
• Maksym Melnychuk (born 1999), Ukrainian football player
• Valentyn Melnychuk (born 1940), Ukrainian men's basketball coach
• Vasyl Melnychuk (born 1957), Ukrainian football referee

• All pages with titles containing Melnychuk
• All pages with titles containing Melnichuk