Masaryk is a Slovak surname. Notable people with the surname include:

• Alice Masaryk (1879–1966), Czech sociologist and one of the founding members of the Czechoslovak Red Cross, the daughter of Tomáš Garrigue Masaryk
• Andy Masaryk (born 1999), Slovak footballer
• Charlotte Garrigue Masaryk, American-born wife of Tomáš Garrigue Masaryk
• Fritzi Massary (1882–1969, born Massaryk), Austrian-American soprano singer and actress
• Herbert Masaryk (1880–1915), Czech painter, the son of Tomáš Garrigue Masaryk
• Jan Masaryk (1886–1948), Czech diplomat and politician, the son of Tomáš Garrigue Masaryk
• Pavol Masaryk (born 1980), Slovak football striker
• Tomáš Garrigue Masaryk (1850–1937), Czech statesman in Austria-Hungary and Czechoslovakia, sociologist, philosopher, and the first President and founder of Czechoslovakia

• Avenida Masaryk, luxury shopping street in Mexico City