MKE may refer to:

• Milwaukee, a city in Wisconsin, United States
  • Milwaukee Intermodal Station; Amtrak station code MKE
  • Milwaukee Mitchell International Airport, IATA airport code MKE
  • Ascent MKE, high-rise building in Milwaukee
  • MKE (tabloid), a weekly publication in Milwaukee (2004–2008)
• MKE Ankaragücü, a Turkish football club in Ankara
• MKE Kırıkkalespor, a Turkish football club in Kirikkale
• Mechanical and Chemical Industry Corporation (Turkey), in Turkish, Makina ve Kimya Endustrisi Kurumu
• MKE (for Matsushita Kotobuki Electronics), an obsolete Panasonic CD interface
• South Korean Ministry of Knowledge Economy (MKE), now the Ministry of Trade, Industry and Energy