M74 or M-74 may refer to:

• M74 light mortar
• M74 motorway, a motorway in Scotland
• Messier 74, a spiral galaxy in the constellation Pisces
• M74 rocket, an incendiary rocket for a shoulder-fired M202A1 FLASH launcher
• M74 armored recovery vehicle, a variant of the M4 Sherman tank
• M-74 (Michigan highway), a former state highway in Michigan
• M74 (or Mk 74), a submunition (bomblet) used with American ATACMS missiles
• M74 syndrome, a disease prevalent in Baltic salmon