M58 or M-58 may refer to:

• Messier 58, a spiral galaxy in the constellation Virgo
• M58 Wolf, an armored vehicle designed to produce a smoke screen
• M58 MICLIC, a mine-clearing charge
• M58 motorway, a motorway in England
• M58 highway, a federal highway in eastern Siberia, Russian Federation
• M58 (Cape Town), a Metropolitan Route in Cape Town, South Africa
• M-58 (Michigan highway), a state highway in Michigan
• 95 S 58-61, a Finnish towed anti-tank weapon
• M-58 (rocket launcher), a Swiss shoulder-fired man-portable anti-tank rocket launcher
• M58 Helmet, an Austrian or Norwegian copy of the M1 helmet