Luzzatto (or Luzzato) is an Italian surname. According to a tradition communicated by S. D. Luzzatto, the family descends from a German Jew who immigrated into Italy from the province of Lusatia, and who was named after his native place.^[1]

Notable people with the surname include:

• Amos Luzzatto (1928–2020), Italian Jewish writer
• Carolina Luzzatto (1837–1919), Italian journalist and writer
• Filosseno Luzzatto (1829–1854), Italian Jewish scholar, son of Samuel David Luzzatto
• Laura Luzzatto Dallapiccola, known as Laura Dallapiccola (1911–1995), Italian librarian and translator
• Moshe Chaim Luzzatto (1707–1746), Italian rabbi, kabbalist, and philosopher
• Samuel David Luzzatto (1800–1865), Italian Jewish scholar, and poet
• Simone Luzzatto (1583–1663), Italian rabbi

• Emanuele Luzzati
• Luigi Luzzatti
• Fiorello La Guardia