Luke may refer to:

• Luke (given name), including a list of people and fictional characters with the name
• Luke (surname), including a list of people with the name
• Luke the Evangelist, author of the Gospel of Luke
• Dr. Luke, American songwriter and record producer Łukasz Sebastian Gottwald (born 1973)
• Uncle Luke, also known as Luke, American rapper Luther Roderick Campbell (born 1960)

• Gospel of Luke, a Christian Gospel

• Luke (album), by Steve Lukather
• Luke (French band)
• "LUKE", a song by Susumu Hirasawa from Glory Wars
• Luke Records, a record label

• Luke (Čajniče), a village in the municipality of Čajniče, Bosnia and Herzegovina
• Luke (Hadžići), a village in Sarajevo Canton, Bosnia and Herzegovina
• Luke (Pale), a village in the municipality of Pale, Bosnia and Herzegovina
• Luke, Vareš, a village in the municipality of Vareš, Bosnia and Herzegovina
• Luke, Estonia, a village in Nõo Parish, Tartu County, Estonia
  • Luke Manor
• Luke, North Macedonia, a village in Kriva Palanka
• Luke (Ivanjica), a village in the municipality of Ivanjica, Serbia
• Luke, Maryland, a town in the United States
• Luke, an oldentime English overname of the Dutch placename Luik, now known as Liege, Belgium; also, an English word for goods such as velvet and iron from Luik
• Luke Air Force Base, Glendale, Arizona, United States
• Luke Field, Ford Island, Hawaii, United States, name of the Army Air Force airfield from 1919 to c. 1939
• Luke railway station, Luke, Manitoba, Canada

• Luke, Natural Resources Institute Finland (Luonnonvarakeskus)
• Luke, a 1970s British boutique run by Gordon Luke Clarke
• Baron Luke, a title in the Peerage of the United Kingdom
• "Luke" (Street Level Hero), an episode of Street Level Hero

• All pages with titles beginning with Luke
• Louka (disambiguation)
• Luka (disambiguation)
• Saint Luke (disambiguation)