Louisville is the largest city in the U.S. Commonwealth of Kentucky.

Louisville may also refer to:

• Louisville/Jefferson County metro government (balance), Kentucky, a statistical entity corresponding to that portion of the consolidated city-county entity that does not include any of the 83 incorporated places in the consolidated city-county
• Louisville metropolitan area

• Louisville, Belize
• Louisville, Alabama
• Greenwood, El Dorado County, California, formerly Louisville, California
• Louisville, Colorado
• Louisville, Georgia, a former capital of Georgia
• Louisville, Illinois
  • Louisville Township, Clay County, Illinois
• Louisville, Kansas
• Louisville Township, Red Lake County, Minnesota
• Louisville Township, Scott County, Minnesota
• Louisville, Mississippi
• Louisville, Chariton County, Missouri
• Louisville, Lincoln County, Missouri
• Louisville, Nebraska
  • Louisville State Recreation Area
• Louisville, New York
• Louisville, Ohio
• Louisville, Adams County, Ohio
• Louisville, Tennessee
• Louisville Ridge, a ridge in the South Pacific Ocean

• USS Louisville (1861), an ironclad steamboat used during the American Civil War
• USS Louisville (ID-1644)), a steamship used in 1918 as a troop transport
• USS Louisville (CA-28), a heavy cruiser commissioned in 1931 and active in World War II
• USS Louisville (SSN-724), a Los Angeles-class nuclear attack submarine in commissioned 1986-2021

• University of Louisville, a public university in Louisville, Kentucky
  • Louisville Cardinals, their intercollegiate athletic program
• Louisville (magazine), a magazine about Louisville, Kentucky

• Lewisville (disambiguation)
• Louis (disambiguation)
• Louiseville
• Louisville Township, Minnesota (disambiguation)
• St. Louisville, Ohio
• USS Louisville, a list of ships