The following highways are numbered 291:

• Manitoba Provincial Road 291
• Quebec Route 291

• Japan National Route 291

• Interstate 291 (multiple highways)
• Alabama State Route 291
• Arkansas Highway 291
• Colorado State Highway 291
• Florida State Road 291
• Georgia State Route 291 (former)
• Kentucky Route 291
• Maryland Route 291
• Minnesota State Highway 291
• Missouri Route 291
• Montana Secondary Highway 291 (former)
• Nevada State Route 291 (former designation for Nevada State Route 140)
• New Mexico State Road 291
• New York State Route 291
  • New York State Route 291 (former)
• Ohio State Route 291
• Pennsylvania Route 291
• South Carolina Highway 291
• Tennessee State Route 291
• Texas:
  • Texas State Highway 291 (former)
  • Texas State Highway Loop 291
  • Farm to Market Road 291
• Utah State Route 291
• Washington State Route 291
• Wyoming Highway 291