La Sierra (Spanish for "the mountain range") may refer to:

• La Sierra (film)
• Rancho La Sierra (Sepulveda), a Mexican land grant including the present-day city of Norco and western end of the city of Riverside
  • La Sierra, California
    • La Sierra Academy, a Seventh-day Adventist K-12 school
    • La Sierra High School, a public high school
    • La Sierra University
    • Riverside – La Sierra station
• Rancho La Sierra (Yorba), a Mexican land grant including the present-day city of Corona
• La Sierra, Encrucijada, Cuba

• Sierra (disambiguation)