La Leona may refer to:

• La Leona (guitar), a famous guitar owned by Miguel Llobet
• La Leona, Costa Rica, a small town in Costa Rica
• La Leona, Texas, a small settlement in Texas, USA
• Paseo La Leona, a pass in Honduras
• Parque La Leona, a park in Honduras
• La Leona River, a river in Argentina
• La Leona (film), a 1964 Argentine film
• La Leona (Argentine telenovela), an Argentine telenovela that aired in 2016
• La Leona (Mexican telenovela), a telenovela that aired in 1961