LSM may refer to:

• Laboratoire Souterrain de Modane (Modane Underground Laboratory), a particle physics laboratory in France
• Lanthanum strontium manganite, a crystal used as a cathode material
• Laser scanning microscopy, a microscopy technique used in biology and nano-crystal imaging
• Least squares method, a method in regression analysis
• LSm, a family of RNA-binding proteins
• LSM-775, a psychedelic drug similar to LSD, although less potent

• Liga Super Malaysia (Malaysia Super League), a top-tier association football league in Malaysia
• Long-stick midfielder, a player position in field lacrosse

• Land Surface Model (LSM version 1.0), a unidimensional computational model
• Latent semantic mapping, for modelling data relationships
• Level-set method, for numerical analysis of interfaces and shapes
• Linear scheduling method, a project scheduling method for repetitive activities
• Linear synchronous motor, an electric motor
• Linux Security Modules, a modular framework for security checks in Linux
• Linux Software Map, file format
• Liquid state machine, a type of neural network
• Live Slow Motion Multicam (LSM), instant-replay software developed by EVS
• Log-structured merge-tree, a data structure

• Lourdes School of Mandaluyong, Philippines
• Louvain School of Management, Belgium

• Law Society of Manitoba
• Lesbian Sex Mafia, a female support group and BDSM organization
• Little St Mary's, an Anglo-Catholic parish in Cambridge
• Living Stream Ministry, religious publisher
• Lutheran Student Movement – USA

• A US Navy hull classification symbol: Landing ship medium (LSM)
• Libre Software Meeting, an annual free software event in France
• San Martín Line (Linea San Martín), commuter rail line in Buenos Aires
• Local store marketing, a marketing term
• Mexican Sign Language (Lengua de Señas Mexicana)
• Latvijas Sabiedriskais medijs (Latvian Public Broadcasting), a publicly funded radio and television organization in Latvia
• Living Standards Measure, a classification of Standard of living in South Africa

• All pages with titles beginning with LSM
• All pages with titles containing LSM