Keep On Truckin' may refer to:

• Keep On Truckin' (comics), a comic and visual motif of underground comix by Robert Crumb

• Keep On Truckin' (The Conners), the 2018 series premiere of the American sitcom The Conners
• Keep On Truckin' (TV series), a 1975 American comedy series

• "Keep On Truckin'" (song), a 1973 song by Eddie Kendricks
• "Ja-Da" or "Keep On Truckin'", a 1918 song written by Bob Carleton
• Keep On Truckin', an album by Dave Dudley, or its title song
• Keep On Truckin', an album by Larry Scott
• "Keep On Truckin'", a song by Pnau from Sambanova
• "Keep On Truckin'", a song by the Road Hammers from The Road Hammers
• "Keep On Truckin", a 1972 song by Hot Tuna from Burgers

• "Truckin'", a song by the Grateful Dead
• "Truckin' My Blues Away", a 1936 song by Blind Boy Fuller, to which the R. Crumb comic refers