Karen Brown may refer to:

• Karen Brown (ballerina) (born 1955), American ballerina and artistic director
• Karen Brown (cricketer) (born 1963), Australian cricketer
• Karen Brown (field hockey) (born 1963), British hockey player
• Karen McCarthy Brown (1942–2015), American anthropologist
• Karen Brown (author), American short story writer, see O. Henry Award
• Karen Brown, Republican candidate in the 2011 Philadelphia mayoral election