John Reese may refer to:

• John Reese (baseball) (1895–?), outfielder in the Negro leagues
• John Reese (cricketer) (1877–1971), New Zealand cricketer
• John D. Reese (1855–1931), American Major League Baseball trainer
• John H. Reese (1910–1981), American author of Western fiction
• John N. Reese Jr. (1923–1945), American posthumous Medal of Honor recipient in World War II
• John P. Reese (born 1953), American money manager and financial columnist
• John Earl Reese (1939–1955), murdered African American teenager
• John Terence Reese (1913–1996), British bridge player and writer
• John Reese, American musical producer for the Uproar Festival

• John Reese (Person of Interest), a main character from the television series Person of Interest
• John Connor, alias in television series Terminator: The Sarah Connor Chronicles

• John Rees (disambiguation)
• John Reese Kenly (1818–1891), American lawyer and Union general in the American Civil War
• John Rhys (1840–1915), scholar
• John Rhys-Davies (born 1944), Welsh actor