John Drake may refer to:

• John Drake (mayor) (died c. 1433), medieval mayor of Dublin
• John Drake (died 1628) (1556–1628), English politician
• John Drake (privateer) (c. 1560–1600s), English pirate
• Sir John Drake, 1st Baronet (1625–1669), English politician
• John R. Drake (New York politician) (1782–1857), U.S. Representative from New York
• John Poad Drake (1794–1883), inventor and artist
• John Drake (1826–1895), American hotel magnate
• John M. Drake (1830–1913), Union Army officer during the American Civil War
• John Drake (1872–1964), American hotel magnate
• John Drake (cricketer) (1893–1967), English cricketer
• Johnny Drake (1916–1973), American football player
• John W. Drake, American microbiologist
• John Drake (rugby union) (1959–2008), New Zealand rugby footballer
• John Drake, singer for the band The Amboy Dukes

• John Drake (Danger Man), character of the eponymous series

• Jack Drake (disambiguation)
• John Drake Sloat