James Wharton may refer to:

• James Wharton, Baron Wharton of Yarm (born 1984), British politician
• James Wharton (author) (born 1987), author and LGBT activist
• James Wharton (boxer) (1813–1856), English boxer
• James Wharton (cricketer) (born 2001), English cricketer
• James Wharton (racing driver), Australian racing driver
• James Edward Wharton (1894–1944), United States Army officer
• J. Ernest Wharton (1899–1990), U.S. Representative from New York