James Sanders may refer to:

• James Sanders (American football) (born 1983), American football safety
• Twiggy Sanders (James Sanders), member of the Harlem Globetrotters
• Jimmy Sanders (footballer) (1920–2003), English goalkeeper, mostly for West Bromwich Albion
• Jimmy Sanders (baseball) (1902–1975), minor league baseball player and manager
• Jim Sanders (footballer) (1932–2007), English footballer, mostly for Crystal Palace and Exeter
• Jim Sanders (rugby league) (1900–1981), New Zealand international

• James Sanders Jr. (born 1957), New York State Senator, 2013-
• James Sanders Holman (1804–1867), first mayor of Houston, Texas

• James Sanders (architect) (born 1955), architect, designer, and writer in New York City
• James Sanders (RAF officer) (1914–2002), British flying ace of the Second World War
• James A. Sanders (1927–2020), Biblical scholar
• James C. Sanders (1926–2018), American businessman and administrator of the Small Business Administration
• Murder of James Sanders, murdered while showing a diamond ring that was listed for sale in Craigslist
• Speed Demon (comics), also known as James Sanders, a Marvel Comics character

• James Saunders (disambiguation)